RT Journal Article
SR Electronic
T1 Age at asthma diagnosis and probability of remission in a population-based study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4641
DO 10.1183/13993003.congress-2020.4641
VO 56
IS suppl 64
A1 Jasmin Honkamäki
A1 Päivi Piirilä
A1 Hanna Hisinger-Mölkänen
A1 Leena E Tuomisto
A1 Heidi Andersen
A1 Heini Huhtala
A1 Anssi Sovijärvi
A1 Helena Backman
A1 Bo Lundbäck
A1 Eva Rönmark
A1 Lauri Lehtimäki
A1 Paula Pallasaho
A1 Pinja Ilmarinen
A1 Hannu Kankaanranta
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/4641.abstract
AB Background: Child-onset asthma is known to remit with high probability but remission in adult-onset asthma seems to be less common. Reports of association between remission and asthma onset age in adulthood are scarce.Objectives: To study if age at asthma diagnosis and gender are associated to remission rate in adult asthma population.Methods: In 2016, a random sample of 16 000 subjects aged 20-69 years from Helsinki and Western Finland were sent a FinEsS-questionnaire. Asthma was categorized by reported age when diagnosed with asthma by a physician: child (0-11 years) adolescent-young-adult (12-39 years) and late-adult-diagnosed (40-69 years). Remission was defined as a physician diagnosed asthma but not having had asthma symptoms, wheezing or use of asthma medication in the past 12 months.Results: 8199 subjects (51.5%) responded to the postal questionnaire. Remission was most common in child-diagnosed (30.2%), followed by adolescent-young-adult-diagnosed (17.9%) and least common in late-adult-diagnosed asthma (5.0%) (p<0.001). In males, the corresponding proportions were 36.7%, 20.0% and 3.4%, and in females 20.4%, 16.6% and 5.9%, respectively (p<0.001 for gender difference). In binary logistic regression, significant risk factors of non-remission were diagnosis at adolescent-young-adulthood- (OR=2.2, 95% CI 1.4-3.4) or late-adulthood- (OR=11.1, 4.8-25.4), asthma-COPD overlap (ACO) (OR=5.6, 1.3-24.5), allergic rhinitis (OR=2.3, 1.5-3.5) and family history of asthma (OR=1.9, 1.2-2.8). Results remained similar after exclusion of ACO.Conclusion: Remission was rare (5%) in adults diagnosed with asthma after age 40 years in both sexes. Causes of poor prognosis in adult-onset asthma need to be further elucidated.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4641.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).