%0 Journal Article %A Christoph Fisser %A Felix Gerhardinger %A Thomas Müller %A Maximilian Malfertheiner %A Alois Philipp %A Maik Foltan %A Dirk Lunz %A Matthias Lubnow %T Predictors for successful weaning from V-V ECMO %D 2020 %R 10.1183/13993003.congress-2020.3432 %J European Respiratory Journal %P 3432 %V 56 %N suppl 64 %X Aim: Despite expanding use of V-V ECMO, little is known on the predictors for successful weaning from V-V ECMO.Methods: Single center study of prospectively collected data (Regensburg ECMO-registry, 10/2011-12/2017). Readiness to ECMO weaning was assumed if underlying disease was controlled and if patient was respiratory (SpO2≥90% on FiO2≤0,4, PEEP≤10, RR<30/min, TV>5ml/kg, ECMO blood flow~1.5l/min) and hemodynamical (HR<120/min, norepinephrine<0.2µg/kg/min) stable. Weaning trial was conducted by turning sweep gas flow off for ≥30min. Weaning failure was defined as subjective (dyspnea, vegetative symptoms) or objective (tachypnea>35/min, SpO2≤90%, HR>120/min, deterioration of ABG) worsening. P100 was defined as pO2 after turning FiO2 (ventilator) to 100% for ≥5min. Predictors were assessed before turning sweep gas flow off.Results: We analyzed 227 patients. ECMO weaning trials were classified in not prolonged, prolonged (>3 weaning attempts) and unsuccessful (169 [75%], 10 [4%], 48 [21%]). In contrast to parameters of oxygenation (pO2/FiO2, oxygen content and P100), hemoglobin and fluid balance; variables of ventilation and work of breathing (pCO2, pH, respiratory rate, driving pressure, RSBI) were associated with weaning success (Table 1).Conclusion: Despite fulfilling criteria for readiness to wean, some weaning attempts failed. Variables reflecting the work of breathing and ventilation but not oxygenation were predictive for successful weaning of V-V ECMO.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3432.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). %U