RT Journal Article
SR Electronic
T1 In vitro fine particle dose of drug formulation used in asthma & COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3185
DO 10.1183/13993003.congress-2020.3185
VO 56
IS suppl 64
A1 Lois Slator
A1 Dirk Von Hollen
A1 Lucy E. A. Hardaker
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/3185.abstract
AB Valved holding Chambers (VHCs) are used with pressurized metered dose inhalers (pMDIs) to counter issues patients have in coordinating pMDI actuation and inhalation. The fine particle dose (FPD <4.7μg) of aerosol from the pMDI & VHC should be similar to the FPD from the pMDI.We reviewed in vitro test results of FPD from the VHC (OptiChamber Diamond; OCD) when used with 7 drugs commonly used for the treatment of asthma and COPD. The 7 pMDI drugs (Table 1) included 2 inhaled corticosteroids (Flovent and QVAR), 1 anticholinergic (Atrovent) and 4 bronchodilator formulations of salbutamol sulphate (SALB; Ventolin Evohaler sold in the UK, Ventolin HFA, Proventil and ProAir HFA sold in the USA). Two pMDI’s were used for each drug except Flovent, QVAR and Atrovent (1 pMDI), all were tested in duplicate. Six new, unwashed VHCs were used for all drugs except QVAR (6 washed VHCs). The FPD of aerosol emitted from either pMDI alone or pMDI with OCD VHC was assessed using a next generation impactor operated at 30 L/min, 10 pMDI actuations were used for each run. View this table:Table 1 Mean FPD (μg ± standard deviation)FPD from the pMDI with VHC was equivalent or greater than pMDI alone. Although the 4 bronchodilator drug formulations delivered the same drug (SALB) the FPD differed by up to a factor of 2.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3185.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).