TY - JOUR T1 - Venous thromboembolism in solid-organ transplant recipients: findings from the RIETE registry JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.3571 VL - 56 IS - suppl 64 SP - 3571 AU - Alberto Garcia Ortega AU - Raquel López Reyes AU - Gabriel Anguera De Francisco AU - Grace Oscullo Yépez AU - Remedios Otero Candelera AU - Manuel López-Meseguer AU - Andrés Quezada AU - Luis Jara-Palomares AU - Manuel Monreal Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/3571.abstract N2 - Introduction: Venous thromboembolism (VTE) represents a relevant cause of morbidity in patients with solid-organ transplantation (SOT), which is recognized as an environmental risk factor for VTE. Nevertheless, there are few data about the management and outcomes in this special population.Methods: The RIETE registry is a worldwide, prospective cohort of consecutive patients presenting with objectively confirmed, acute VTE. We used the data from RIETE registry to describe the clinical and therapeutic characteristics in this population and to assess the outcomes of VTE during SOT.Results: Of 83,210 patients with VTE, SOT was reported in 329 (0.4%) patients. Of these, there were 221 kidney transplant recipients (TR), 41 liver TR, 28 lung TR and 25 heart TR. Patients with SOT were younger, more likely men and to have cardiovascular risk factors or recent surgery, and less likely to have active cancer. VTE in SOT recipients were initially presented with PE less frequently (34% vs 53%). Both anemia and plaquetopenia, and kidney insufficiency (60% vs 35%) were more likely in patients with SOT. Concerning long-term therapy, treatment duration was shorter in the SOT patients (255 vs 289 days), more often with LMWH [OR 1.64 (1.31-2.05)], and less often with DOAC [OR 0.36 (0.19-0-68)]. During the course of anticoagulation, the incidence of bleeding in the SOT recipients was higher, both major [HR 2.55 (1.62-3.84)] and non-major [HR 1.94 (1.23-2.93)]. There were no differences in the rate of recurrent VTE or overall mortality, but bleeding was the explanation of death more frequently in TR [HR 3.28 (1.20-7.33)].Conclusions: VTE is associated with increased risk of bleeding in SOT recipients.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3571.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -