RT Journal Article
SR Electronic
T1 Late Breaking Abstract - Persisting pulmonary impairment following severe SARS-CoV-2 infection, preliminary results from the CovILD study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4143
DO 10.1183/13993003.congress-2020.4143
VO 56
IS suppl 64
A1 Sabina Sahanic
A1 Thomas Sonnweber
A1 Alex Pizzini
A1 Gerlig Widmann
A1 Anna Luger
A1 Magdalena Aichner
A1 Anna Böhm
A1 Guenter Weiss
A1 Christoph Tschurtschenthaler
A1 Verena Petzer
A1 David Haschka
A1 Markus Theurl
A1 Daniela Lener
A1 Sophie Wildner
A1 Rosa Bellmann-Weiler
A1 Ewald Wöll
A1 Judith Löffler-Ragg
A1 Ivan Tancevski
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/4143.abstract
AB Background: In the 2002/2003 SARS1 outbreak, 30% of survivors exhibited persisting structural pulmonary abnormalities months after infection. Yet to this day, there is no follow-up data in patients after severe COVID-19.Aims: In this prospective multicentre observational study, we aim to systematically evaluate the cardio-pulmonary damage in COVID-19 survivors at 6, 12, and 24 weeks after discharge.Methods: At each visit, clinical examination, laboratory testing, blood gas analysis, lung function, thoracic HR-CT and echocardiography are conducted.Results: Preliminary data from 82 consecutive patients was evaluated at the first follow-up visit, i.e. 6 weeks after discharge. Mean age was 56.7 years (63.4% males); 43.9% of patients had a positive smoking history. 54 patients (65.9%) exhibited persistent symptoms, with dyspnoea ranking highest (36.6%), followed by cough (19.5%). 20 patients (24.4%) showed persistent lung impairment (defined as FVC <80% and/or FEV1 <80%), while 31 patients (37.8%) showed signs of hyperinflation (defined as RV >120%). 23 patients (28%) showed reduced diffusion capacity (DLCO). 48 patients (58.5%) showed left ventricular diastolic dysfunction. Importantly, serum NT-proBNP, D-dimer, and ferritin levels were found significantly elevated.Conclusion: A major portion of COVID-19 survivors presented with persisting dyspnoea and lung function abnormalities. Altogether, our results indicate prolonged resolution and remodelling, implementation of our HR-CT scan findings will finally be key to exactly define the cardio-pulmonary damage after COVID-19. We are eager to present our data of 6 and 12 weeks follow-ups at the ERS 2020.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4143.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).