TY - JOUR T1 - Impact of obstructive sleep apnea and obesity on endothelial dysfunction in children JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.3951 VL - 56 IS - suppl 64 SP - 3951 AU - Emilie Mylemans AU - Sofie Jacobs AU - Eline Vermeiren AU - Kim Van Hoorenbeeck AU - Ann De Guchtenaere AU - Annelies Van Eyck AU - Stijn Verhulst Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/3951.abstract N2 - Background: Endothelial dysfunction in children can arise in the context of both obesity and obstructive sleep apnea (OSA). The interactions between these variables together is not clearly understood.Aims and Objectives: To investigate the effect of weight loss on endothelial function and OSA in an obese population and whether a change in endothelial function can be linked to an improvement in OSA?Methods: Children aged 8 to 18 in a 12 month inpatient weight loss program at Zeepreventorium De Haan were recruited. Anthropometry and endothelial function (measured as time to peak response (TPR) by EndoPAT) were collected at baseline, at 12 and at 18 months. At baseline a sleep screening with ApneaLink was performed. This was repeated after 12 months in the presence of OSA.Results: 130 children were included of which 87 had OSA (67%). Only 71 and 28 patients attended follow-up at 12 and 18 months. After 12 months, 10 patients had residual OSA (treatment succes rate of 78.7%). Weight parameters decreased after 12 months (from an average of 2.7 BMI z score to 1.7; p<0.001) with variable effect after 18 months (BMI z score 1.75; p<0.001*). TPR improved after weight loss (195s to 135s; p=0.002) and did not elongate after 18 months (135s; p=0.002*). Patients with residual OSA had a higher TPR at 12 months compared to those with normalized OSA (225s vs 105s; p=0.01). Linear mixed models analysis showed that the improvement of TPR was significantly influenced by OSA (p=0.039).Conclusions: Weight loss improves endothelial function in an obese pediatric population. However, even after weight loss, endothelial function is less likely to improve in the presence of OSA.*p values between baseline and 18 monthsFootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3951.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -