PT  - JOURNAL ARTICLE
AU  - Olivier Van Hove
AU  - Vasileios Andrianopoulos
AU  - Ana Maria Cebolla
AU  - Dimitri Leduc
AU  - Véronique Feipel
AU  - Gaël Deboeck
AU  - Bruno Bonnechère
TI  - The influence of various inspiratory loads on reaction time in healthy subjects
AID  - 10.1183/13993003.congress-2020.3217
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 3217
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/3217.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/3217.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Background: There is an association between breathing and cognitive function. Increased inspiratory loads (IL) are related to decreased performance in locomotor tasks requiring cognitive inputs. We aimed to investigate this relationship by using cognitive mobile games (CMG) that assess changes in reaction time (RT) induced by various acute respiratory loads in healthy subjects.Methods: Twenty-four healthy subjects (25±4 years old, 12 women) were recruited. A set of two validated short CMG was used to assess the RT: Must Sort (task-shifting and inhibition) and True Color (stroop-test like) in control situation and at four different IL (through a mouthpiece without resistance (MP) and with 10, 50 and 70% of the maximal inspiratory pressure). Dyspnea was assessed after each session by A1 score (breathing discomfort) of the Multidimensional Dyspnea Profile questionnaire.Results: Increased RT after 4 different IL was observed in the Must Sort (p for linear trend <.001): 328±78ms (MP), 333±77ms (10%), 368 ±68ms (50%), 399±117ms (70%) vs 286±56ms (control) and True Color (p for linear trend <.001): 1399±366ms (MP), 1337±256ms (10%), 1560±569ms (50%), 1570±414ms (70%) vs 1241±229ms (control). Dyspnea was increased after IL in A1: 1±2 (MP), 3±2 (10%), 5±2 (50%), 6±2 (70%); Correlations between the dimension A1 and the RT were detected: r=0.34 (p<.001) for the Must Sort and r=0.34 (p<.001) for the True Color.Conclusion: Breathing with an inspiratory load is associated with increased dyspnea and increased reaction time. Dyspnea influences the reaction time suggesting interference with perceptual-motor tasks.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3217.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).