RT Journal Article SR Electronic T1 Role of craniofacial and upper airway profile assessment in pediatric obstructive sleep apnea(OSA)- a prospective case control study from India JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 224 DO 10.1183/13993003.congress-2020.224 VO 56 IS suppl 64 A1 Rahul K. Sharma A1 Ankita Goel Sharma A1 Shibdas Chakrabarti A1 J C Suri YR 2020 UL http://erj.ersjournals.com/content/56/suppl_64/224.abstract AB Background: Pediatric OSA has multifactorial predisposing conditions like adenotonsillar hypertrophy, craniofacial abnormalities and obesity. Correlating data between cephalometry/upper airway assessment parameters and pediatric OSA is sparse.Aim: To evaluate upper airway and craniofacial characteristics in pediatric OSA and their association with disease severity.Methods: 40 confirmed OSA cases aged 3-15 years were compared with 40 matched controls by clinical assessment(physical parameters), lateral cephalometry(bony distances and angles) and MRI neck(soft tissue assessment).Results: Twenty-one cases had severe, 12 moderate and 7 had mild OSA. Tonsillar hypertrophy, retrognathia, overcrowding of teeth, overjet and higher modified Mallampati score were significantly more in cases. Retrognathia correlated with severity of OSA(p=0.029).On cephalometry, hyomandibular distance,mandibular inclination angle(SnGoGn), intermaxillar angle, narrowest retropalatal distance and lower anterior facial height showed significant difference between two groups. On MRI neck, soft palate length was greater (27.09+5.59 vs 24.24+2.69 mm, p=0.005), while narrowest retropalatal (5.03+1.69 vs 7.61+2.72mm,p=0.0) and retroglossal oropharyngeal distances (NRGOD)(9.63+3.22 vs 11.81+5.84mm,p=0.04) was significantly lower in cases. Intermaxillar angle(r=-0.44,p=0.004), SnGoGn(r=0.42,p=0.007) and NRGOD(r=0.34, p=0.03) correlated significantly with OSA severity.Conclusion: Craniofacial profiling by physical examination, lateral cephalometry and MRI neck are important adjuncts in assessment of pediatric OSA to identify at risk subjects and predict disease severity.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 224.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).