PT  - JOURNAL ARTICLE
AU  - Emmanuel Aris
AU  - Esse Ifebi Akpo
AU  - Amit Bhavsar
AU  - Lauriane Harrington
AU  - Evie Merinopoulou
AU  - Nicola Sawalhi-Leckenby
AU  - Elisa Turriani
AU  - Kinga Meszaros
AU  - Dimitra Lambrelli
AU  - Piyali Mukherjee
TI  - Late Breaking Abstract - The burden of pertussis in adults with asthma: a retrospective database study in England
AID  - 10.1183/13993003.congress-2020.4926
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 4926
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/4926.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/4926.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Introduction: Pertussis is under-recognized in older adults, especially those with chronic conditions like asthma. It is important to estimate the incidence and economic burden of pertussis in these populations.Objectives: To estimate the burden of reported pertussis cases among ≥50-year-olds (≥50yo) and in an asthma sub-population (≥50yo+Asthma) in England, 2009-18.Methods: A retrospective observational study was conducted using the Clinical Practice Research Datalink, GOLD and Aurum databases, linked to Hospital Episode Statistics. Occurrence of pertussis and asthma were identified by diagnostic codes. Incidence rates (IRs) of pertussis among ≥50yo and ≥50yo+Asthma cohorts were estimated. Healthcare resource utilization will be presented in the poster.Results: Among ≥50yo, 28.5 million (m) person-years follow-up (PYFU) were included, with 3.6m PYFU ≥50yo+Asthma. Across the study period, IRs of pertussis were statistically higher in ≥50yo+Asthma than the ≥50yo cohort (9.61 (95% CI: 8.63-10.68) and 5.76 (5.48-6.04) /100,000 PYFU, respectively), with point estimates consistently higher over time. Observed IRs decreased with age in both groups.Conclusions: The incidence of diagnosed pertussis was higher among ≥50yo+Asthma patients than the ≥50yo cohort. Considering other literature suggesting under-diagnosis of pertussis, further research is warranted on the potential health and economic impact of pertussis in asthmatics.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4926.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).