RT Journal Article SR Electronic T1 Effects of game based approach in patients with primary ciliary dyskinesia: a randomized controlled trial JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 4111 DO 10.1183/13993003.congress-2020.4111 VO 56 IS suppl 64 A1 Hazal Sonbahar Ulu A1 Deniz Inal Ince A1 Melda Saglam A1 Aslihan Cakmak A1 Naciye Vardar Yagli A1 Ebru Calik Kutukcu A1 Erkan Sumer A1 Hayriye Ugur Ozcelik YR 2020 UL http://erj.ersjournals.com/content/56/suppl_64/4111.abstract AB Background: Pulmonary function and exercise capacity are affected in patients with primary ciliary dyskinesia (PCD). We aimed to investigate the effects of game based approach (GBA) program on pulmonary function, exercise capacity, respiratory and peripheral muscles, and functional status in patients with PCD.Method: Thirty-two PCD patients were included into the study. Patients were randomly assigned the GBA group (n=16) or the control group (n=16). The GBA group underwent GBA using Xbox Kinect 360 device for 40 min/day, three days/week for eight weeks plus airway clearance therapy (ACT), and the control group applied ACT only. Pulmonary function was recorded. Respiratory muscle strength (maximal inspiratory pressure [MIP] and maximal expiratory pressure [MEP]) was evaluated using a mouth pressure device. Peripheral muscle strength (knee extensors and shoulder abductors) was assessed using hand-held dynamometer. Exercise capacity was evaluated using six-minute walk test (6MWT), and functional status was assessed using the Glittre activities of daily living (ADL) test before and after eight weeks.Results: GBA resulted in significant improvements in pulmonary function, MIP, MEP, knee extensor and shoulder abductor strength, 6MWT distance, and functional status in the GBA group (p<0.05). There was no significant difference in measured parameters after during the study period in the control group (p>0.05).Conclusion: GBA has positive effects on the pulmonary function, respiratory and peripheral muscles, exercise capacity, and functional status in patients with PCD. GBA can be added to the pulmonary rehabilitation program as an exercise training modality in patients with PCD.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4111.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).