PT  - JOURNAL ARTICLE
AU  - Olga Nesterovska
AU  - Ganna Stupnytska
AU  - Oleksandr Fediv
AU  - Oksana Pritulyak
AU  - Iryna Nemish
TI  - An Evaluation of Slow Vital Capacity and Forced Vital Capacity Difference in Aco Patients with Obesity
AID  - 10.1183/13993003.congress-2020.3077
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 3077
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/3077.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/3077.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - While COPD is characterised by an accelerated, although variable FEV1 decline , many ACO patients experience a slow decline in lung function. Among subjects with ACO, FEV1/FVC ratio may miss airflow limitation. It remains unclear whether using SVC instead of FVC increases the detecting of airflow limitation in ACO patients with obesity.Objectives: To investigate the differences between SVC and FVC in ACO patients with obesity.Methods: Subjects (n=255) aged 50–64 years were investigated with FEV1, FVC, and SVC . All spirometric maneuvers were performed before and 15 minutes after inhalation of 400 μg of salbutamol. The 2005 ATS / ERS recommendations were used to evaluate the spirometric results.Results: The main demographic indicators of the study cohort included 68% of men and 32% of women, with an average age of 58.7 years. The 23.4% of patients had preserved or mildly reduced obstruction, 38.7% moderate, 26.75%- severe and 11.2% had very severe obstruction . The most subjects diagnosed with airflow obstruction according to FEV1/ SVC only had mildly reduced FEV1. Among people with normal spirometry,22,4% had a SVC-FVC difference of more than 500 ml. Patients with BMI > 30 kg/m2 were associated with airflow obstruction diagnosed only by FEV1/ SVC.Conclusions: Our research demonstrates great differences between FVC and SVC values . There is a greater difference between these indicators in subjects with preserved or mild obstruction This indicates that FEV1/SVC relation is the most reliable in the detection of an obstruction in ACO patients with obesity.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3077.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).