RT Journal Article SR Electronic T1 The roles of human bocavirus and human metapneumovirus in lower respiratory tract infections in children JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1151 DO 10.1183/13993003.congress-2020.1151 VO 56 IS suppl 64 A1 Dilber Ademhan Tural A1 Ebru Yalcin A1 Nagehan Emiralioglu A1 Alparslan Alp A1 Onur Gozmen A1 Beste Ozsezen A1 Birce Sunman A1 Deniz Dogru A1 Ugur Ozcelik A1 Nural Kiper YR 2020 UL http://erj.ersjournals.com/content/56/suppl_64/1151.abstract AB Aim: Human bocavirus (HBoV) and human metapneumovirus (HMPV) are two common viruses detected in lower respiratory tract infections (LRTI). In this study, we aimed to compare HBoV and HMPV infections clinically and analyze the effects of coinfections on clinical features and disease severity in a tertiary hospital.Methods: 125 children with LRTI due to HBoV or HMPV which was detected from nasal swap by real-time PCR during Jan2013-Dec2017 were enrolled in the study. The patients were divided into 4 groups; HoBV only (Group 1, n:41), HMPV only (Group 2, n:19), coinfected with HBoV and other respiratory viruses (Group 3, n:101), coinfected with HMPV and other respiratory viruses (Group 4, n:23).Results: 89% of the patients were 5 years old or younger. 72% of them were diagnosed with pneumonia. Coinfections with other respiratory viruses were significantly more common in HBoV infected patients (p:0.001). The most commonly identified virus was human rhino virus in Groups 3 and 4. The hospitalization and antibiotic requirements were significantly higher in Group 1 than Group 3 (p: 0.005, 0.039, resp.). Patients with nosocomial pneumonia had a longer hospitalization duration in Group 3 than Group 4 (p:0.032). According to the logistic regression analyses, the risk of prolonged hospitalization duration increased by 29.5 times (p:0.005) with age (under the age of 5) and 21.7 times with HBoV infections (p:0.006).Conclusion: HBoV and HMPV infections are serious etiological pathogens in children resulting in hospitalization regardless of coinfection status.HBoV causes prolonged hospitalization duration in children with nosocomial pneumonia.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1151.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).