PT  - JOURNAL ARTICLE
AU  - Dilber Ademhan Tural
AU  - Ebru Yalcin
AU  - Nagehan Emiralioglu
AU  - Alparslan Alp
AU  - Onur Gozmen
AU  - Beste Ozsezen
AU  - Birce Sunman
AU  - Deniz Dogru
AU  - Ugur Ozcelik
AU  - Nural Kiper
TI  - The roles of human bocavirus and human metapneumovirus in lower respiratory tract infections in children
AID  - 10.1183/13993003.congress-2020.1151
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 1151
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/1151.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/1151.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Aim: Human bocavirus (HBoV) and human metapneumovirus (HMPV) are two common viruses detected in lower respiratory tract infections (LRTI). In this study, we aimed to compare HBoV and HMPV infections clinically and analyze the effects of coinfections on clinical features and disease severity in a tertiary hospital.Methods: 125 children with LRTI due to HBoV or HMPV which was detected from nasal swap by real-time PCR during Jan2013-Dec2017 were enrolled in the study. The patients were divided into 4 groups; HoBV only (Group 1, n:41), HMPV only (Group 2, n:19), coinfected with HBoV and other respiratory viruses (Group 3, n:101), coinfected with HMPV and other respiratory viruses (Group 4, n:23).Results: 89% of the patients were 5 years old or younger. 72% of them were diagnosed with pneumonia. Coinfections with other respiratory viruses were significantly more common in HBoV infected patients (p:0.001). The most commonly identified virus was human rhino virus in Groups 3 and 4. The hospitalization and antibiotic requirements were significantly higher in Group 1 than Group 3 (p: 0.005, 0.039, resp.). Patients with nosocomial pneumonia had a longer hospitalization duration in Group 3 than Group 4 (p:0.032). According to the logistic regression analyses, the risk of prolonged hospitalization duration increased by 29.5 times (p:0.005) with age (under the age of 5) and 21.7 times with HBoV infections (p:0.006).Conclusion: HBoV and HMPV infections are serious etiological pathogens in children resulting in hospitalization regardless of coinfection status.HBoV causes prolonged hospitalization duration in children with nosocomial pneumonia.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1151.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).