RT Journal Article
SR Electronic
T1 Association of low-intensity smoking with respiratory and lung cancer mortality
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4389
DO 10.1183/13993003.congress-2020.4389
VO 56
IS suppl 64
A1 Balte, Pallavi
A1 Bhatt, Surya
A1 Chaves, Paulo
A1 Couper, David
A1 Freedman, Neal
A1 Jacobs Jr, David
A1 Jones, Miranda
A1 Kalhan, Ravi
A1 Mathew, Amanda
A1 Kronmal, Richard
A1 Loehr, Laura
A1 London, Stephanie
A1 Newman, Anne
A1 O'Connor, George
A1 Schwartz, Joseph
A1 Smith, Benjamin
A1 Smith, Lewis
A1 White, Wendy
A1 Yende, Sachin
A1 Oelsner, Elizabeth
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/4389.abstract
AB Background: The number of current smokers has reached its lowest level to date in the US but the proportion of smokers smoking <10 cigarettes per day (CPD) has increased from 16% to 27%, and many consider “light” smoking to be low risk.Aim: To assess relative risks of respiratory and lung cancer mortality in low-intensity smokers.Methods: Data from 4 US general population cohorts were harmonized and pooled. Current smokers were categorized by self-reported CPD (<10, 10-20, 20+). Adjudication/administrative criteria were used to classify respiratory and lung cancer deaths. Associations were tested via competing risk regression adjusted for sociodemographic factors.Results: Of 18,730 participants (mean age 61 yrs, 56% women, 69% white, 13% current smokers, 17 yrs median follow-up), 649 (IDR=20/10,000 person-years) died from respiratory causes while 560 (IDR=17) died from lung cancer. Compared to never smokers, those with <10CPD had higher risk of respiratory (HR=2.5,P=0.005) and lung cancer (HR=8.6,P=<.0001) mortality. The risks of respiratory and lung cancer mortality associated with <10CPD smoking were 49% and 71%, of the risks of 20+CPD smoking. Results were slightly attenuated after adjusting for smoking duration.Conclusions: Risk of respiratory and lung cancer deaths among low-intensity current smokers vs never smokers, is non-trivial: in this study, this risk was equivalent to at least half that seen in those with 20+CPD.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4389.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).