RT Journal Article
SR Electronic
T1 The long-term clinical and economic impact of COPD exacerbations: an observational study (SHERLOCK)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4910
DO 10.1183/13993003.congress-2020.4910
VO 56
IS suppl 64
A1 John Haughney
A1 Amanda J Lee
A1 Mintu Nath
A1 Hana Müllerová
A1 Ulf Holmgren
A1 Enrico De Nigris
A1 Bo Ding
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/4910.abstract
AB Background: Exacerbations are an important driver of disease progression in COPD and are a key target for patient management. An observational retrospective cohort Study of HEalthcare Resource utiLisation related to exacerbatiOns in patients with COPD (SHERLOCK; D5980R00014) evaluated the clinical impact of exacerbations in primary care patients.Objective: To evaluate associations between exacerbation history and subsequent exacerbations in COPD.Methods: Patients in NHS Scotland ≥40 years of age with COPD were stratified by exacerbation history in the prior year: Group A (none), B (1 moderate), C (1 severe) and D (≥2 moderate and/or severe). Exacerbation rate and type were assessed over 3 years. Rate ratios (RR) were calculated versus the patients in Group A.Results: Overall, 22,462 patients were included. Over 1 year, moderate or severe exacerbation rates for the groups were 0.69 (A), 1.20 (B) and 1.27 (C) per person per year (Table). Patients with prior exacerbations had an increased likelihood of moderate or severe exacerbation during follow-up (B+C: 71%; B: 70%; C: 87%) versus patients in Group A. Data remained consistent over 3 years.Conclusions: In patients with COPD, increased likelihood and rate of subsequent exacerbation was observed after one prior exacerbation. Targeting patients with an exacerbation history may reduce related healthcare costs and support decision-makers with demand planning.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4910.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).