TY - JOUR T1 - Safety Analysis of Superior Vena Cava Resection for Extended Thymic Epithelial Neoplasms> JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.4092 VL - 56 IS - suppl 64 SP - 4092 AU - Luca Bertolaccini AU - Elena Prisciandaro AU - Giulia Sedda AU - Lorenzo Spaggiari Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/4092.abstract N2 - Background: infiltration of superior vena cava (SVC) is not rare. The extent of SVC resection depends on the width of the area of neoplastic invasion.Aims: To evaluate the safety of extended thymectomy for Thymic Epithelial Neoplasm (TEN) with SVC resection.Methods: Retrospectively review of thymectomy for TEN in the last twenty years according to STROBE methodology. Disease-free survival (DFS) and overall survival (OS) were calculated using the Kaplan – Meier method. A backward stepwise Cox regression multivariate analysis was performed to determine factors associated with long-term outcomes.Results: 78 patients underwent surgery for advanced-stage TEN (1998 - 2019). 17.9% underwent thymectomy with resection of SVC. Thymic carcinoma was a negative prognostic factor (HR = 2.26; 95% CI = 1.82 – 6.18; p = 0.038) at the multivariate analysis. The median OS and the DFS of SVC resected patients were 50 months (range: 5 – 207) and 31 months (range: 5 – 151). There was no significant difference in OS and DFS between SVC resected and not resected patients.Conclusions: SVC resection is a safe and effective procedure and does not seem to affect survival and disease recurrence. This surgical approach is oncologically reliable to allow radical resection of locally advanced TEN.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4092.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -