PT - JOURNAL ARTICLE AU - Hrefna Katrín Gudmundsdóttir AU - Katarina Hilde AU - Karen Eline Stensby Bains AU - Martin Färdig AU - Kai-Håkon Carlsen AU - Guttorm Haugen AU - Marissa Leblanc AU - Live Solveig Nordhagen AU - Björn Nordlund AU - Eva Maria Rehbinder AU - Håvard O. Skjerven AU - Anne Cathrine Staff AU - Riyas Vettukattil AU - Karin C. Lødrup Carlsen TI - Late Breaking Abstract - Fetal thoracic circumference in mid-pregnancy and infant lung function AID - 10.1183/13993003.congress-2020.2815 DP - 2020 Sep 07 TA - European Respiratory Journal PG - 2815 VI - 56 IP - suppl 64 4099 - http://erj.ersjournals.com/content/56/suppl_64/2815.short 4100 - http://erj.ersjournals.com/content/56/suppl_64/2815.full SO - Eur Respir J2020 Sep 07; 56 AB - Background and Aim: Impaired lung function in early infancy is associated with later wheeze and asthma, while fetal thoracic circumference (TC) may predict severity of neonatal lung hypoplasia. To explore fetal origins of aberrant lung development we aimed to determine if mid-pregnancy fetal TC was associated with lung function in healthy 3-month old infants.Methods: From the Scandinavian general population-based PreventADALL birth cohort (n=2701), 716 infants had ultrasound measures of TC at around 18 weeks gestational age (GA) and tidal flow volume measures in the awake state at three months of age. Fetal TC correlates strongly with fetal age, estimated by head circumference (HC). Thus, the association between the ratio TC/HC and infant time to Peak Tidal Expiratory Flow to Expiratory time (tPTEF/tE) was analyzed, by linear regression. Maternal asthma, infant sex, GA at birth, birthweight, postnatal age in days, weight, length, respiratory rate, time since last feeding and if the infant had ever been examined for respiratory symptoms were included as covariates. Outcomes were a tPTEF/tE <0.25 or in the lowest 10, 25 or 50 percentiles as well as tPTEF/tE as a continuum.Results: The infants were 47.5% girls. The mean (min, max) GA at birth was 40.2 (35.3, 42.4) weeks and weight at three months 6.3 (4.4, 8.9) kg. The mean (min, max) TC/HC was 0.75 (0.61, 0.93) and tPTEF/tE 0.39 (0.19, 0.60). Five infants had a tPTEF/tE <0.20 while 10% had a tPTEF/tE <0.28. Fetal TC/HC was not associated with tPTEF/tE in simple regression models (p-values 0.10-0.22) or when adjusted for covariates (p-values 0.38-0.83).Conclusion: Fetal TC/HC in mid-pregnancy was not associated with tPTEF/tE in healthy awake 3-month old infants.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2815.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).