RT Journal Article
SR Electronic
T1 Species diversity of non-tuberculous mycobacteria isolated from HIV-positive and HIV-negative patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2357
DO 10.1183/13993003.congress-2020.2357
VO 56
IS suppl 64
A1 Anna Panova
A1 Alexandra Gracheva
A1 Anatoliy Vinokurov
A1 Galina Pay
A1 Grigory Kaminskiy
A1 Eduard Karamov
A1 Irina Vasilyeva
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/2357.abstract
AB Species diversity of non-tuberculous mycobacteria isolated from HIV-positive and HIV-negative patientsIntroduction: The incidence of mycobacteriosis is growing due to an increase in the number of immunocompromised patients, including those with HIV infection. The species diversity of non-tuberculous mycobacteria (NTM) in patients with different HIV statuses is not well understood.Aims and Objectives: Compare species diversity of NTM in HIV-positive (HIV+) and HIV-negative (HIV-) patients.Methods: We conducted a retrospective study of NTM infections at the National Center for Phthisiopulmonology and Infectious Diseases in 2018-2019. All patients were divided into two groups: HIV+ (54 patients) and HIV- (85 patients). Both groups of patients had isolated NTM and mycobacteriosis was diagnosed. NTM isolates were obtained using MGIT and FX systems (BD, USA). Identification was carried out using MALDI-TOF MS (Bruker, Germany).Results: The Mycobacterium avium complex (MAC) prevailed in both groups, beeing more common in HIV+ patients than in HIV- patients: 98.1% versus 60.0% (p <0.001). Of the causative agents of MAC infection, M. avium predominates in both groups, but is most often found in HIV+ group: in 96.3% versus 40.0% (p <0.001). M. intracellulare was less common: 1.9% versus 20.0% (p <0.001). The following most common species were also identified in HIV- groups: M. abscessus (11.8%), M. kansasii (10.6%), M.lentiflavum and M.fortuitum (3.5%)Conclusion: In group with HIV+, the main species of NTM is M.avium. In patients with HIV -, the NTM spectrum is more diverseFootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2357.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).