PT  - JOURNAL ARTICLE
AU  - James Allinson
AU  - Shoaib Afzal
AU  - Yunus Colak
AU  - Helena Backman
AU  - Maarten Van Den Berghe
AU  - Marike Boezen
AU  - Marie Breyer
AU  - Robab Breyer-Kohansal
AU  - Otto C. Burghuber
AU  - Rosa Faner
AU  - Sylvia Hartl
AU  - Deborah Jarvis
AU  - Lies Lahouse
AU  - Arnulf Langhammer
AU  - Bo Lundback
AU  - Bright Nwaru
AU  - Eva Ronmark
AU  - Sigrid Vikjord
AU  - Judith Vonk
AU  - Sara Vijnant
AU  - Viktoria Szabo
AU  - Alvar Agusti
AU  - Gavin Donaldson
AU  - Jadwiga Wedzicha
AU  - Jorgen Vestbo
AU  - Lowie Vanfleteren
TI  - Collating data from major European population studies – The CADSET (Chronic airway disease early stratification) clinical research collaboration
AID  - 10.1183/13993003.congress-2020.3757
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 3757
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/3757.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/3757.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Background: European population cohorts continue to expand our understanding of chronic airways disease and inter-study collaboration may help address the inevitable limitations of study size, duration, era and geography. Towards this aim, CADSET has collated data from ten major general population European cohorts: Asklepios; Copenhagen City Heart Study; Copenhagen General Population Study; ECRHS; HUNT; LEAD; Lifelines, OLIN, Rotterdam Study and WSAS. We included males and females aged 20 to 95 years with baseline demographic and spirometry data.Results: Data from 262,829 individuals (44% male) from multiple European countries provided good coverage across all adult ages (Fig.1A). Recruitment occurred in every year from 1976 through 2020. 23% were current-smokers and 42% were never-smokers, a pattern varying with advancing age (Fig.1B). The prevalence of airflow limitation varied according to whether lower limit of normal (LLN) or <0.70 thresholds were applied, increasing with age if the latter was used (Fig.1C).Interpretation: These results fit with previous reports, however the size, geographical reach and span of recruitment provided by this collaboration provides a unique opportunity to explore chronic airways disease development. Together, we are now pursuing research questions previously beyond the scope of individual cohort studies.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3757.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).