TY - JOUR T1 - Clinical and functional features of pulmonary tuberculosis in young patients depending on the respiratory muscles strength JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.2812 VL - 56 IS - suppl 64 SP - 2812 AU - Sofia Kovaleva AU - Larisa Kiryukhina AU - Nina Denisova AU - Kirill Bolotov AU - Elena Kokorina AU - Natalia Nefedova AU - Lyudmila Archakova Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/2812.abstract N2 - Measuring maximum respiratory pressure is common throughout the world to evaluate respiratory muscle function. Ineffective work of respiratory muscles can be a predictor of an infectious process in the lungs, in particular tuberculosis (TB) due to the development of inefficiency of ventilation processes.Methods: This is a prospective single center study including 84 verified TB patients from 18 to 45 years and divided for 2 groups: 1st group – 36 patients (27M/9F; 30,7±5,6yrs) with muscle disorders (MD), 2nd group - 48 control patients (26/22F; 30,7±7,17yrs) without MD.The patients after lung resection, with AIDS and diabetes were not included.Ventilation parameters we evaluted by spirometry, bodyplethysmography, diffusion capacity and respiratory muscle strength investigation - maximal inspiratory (MIP) and expiratory pressures (MEP). Descriptive statistics, Mann-Whitney test, Spearman correlation analysis were used.Results: In the 1 group MEP was decreased to 61.4±11.8% predicted; MIP – 76.2±24.2%. In the control group mean MEP was 102.2±17.2%; MIP - 86.7±25.1%.In patients with MD, the most common TB forms were disseminated, cavities - only in this group was a generalization of TB infection. The most common forms of pulmonary TB in the control group were infiltrates, tuberculoma, and only in this group, we met TB pleurisy.Patients with MD have a tendency to decrease total lung capacity (p=0.03) and vital capacity (p<0.01), increase residual volume (p=0.01).Conclusions: Young MD patients have more severe forms of tuberculosis. In this group, ventilation disorders tended to obstructively remodel the total lung capacity and significantly decrease MEP.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2812.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -