PT - JOURNAL ARTICLE AU - Josué Pinto AU - Bruno Chambel AU - Cláudia Freitas AU - Mariana Conceição AU - António Morais AU - Gabriela Fernandes AU - Adriana Magalhães AU - Hélder Novais Bastos TI - Spirometry as an integral part of benign tracheal stenosis management AID - 10.1183/13993003.congress-2020.2844 DP - 2020 Sep 07 TA - European Respiratory Journal PG - 2844 VI - 56 IP - suppl 64 4099 - http://erj.ersjournals.com/content/56/suppl_64/2844.short 4100 - http://erj.ersjournals.com/content/56/suppl_64/2844.full SO - Eur Respir J2020 Sep 07; 56 AB - Background: Benign tracheal stenosis (BTS) management is challenging. Though bronchoscopy is the gold standard for diagnosis, its inherent risks make it a less than ideal follow-up method. Previous studies from the 70s established spirometry as a quantitative tool for evaluation of BTS, but scarce research was conducted since. This study aimed to correlate spirometric values with anatomical grading and severity of BTS.Methods: Patients with BTS followed in our department were recruited. Data was collected by patient interview and by consulting the clinical file. Respiratory function tests and cervico-thoracic imaging were performed within 6 months. Stenosis severity was measured using image analysis software applied to radiological images. Data analysis was performed to assess the correlation between spirometric values and stenosis features.Results: Of 28 patients enrolled (mean age 55.1±15.9 years, 53.6% female), 89.3% had complex stenosis. The most common etiology was post-intubation (67.8%) and the most common location was subglottic (71.4%). Regarding stenosis severity, 60.7% presented <50% of airway narrowing. Tracheal narrowing >50% was associated with higher FEV1/PEF ratio and lower PEF% value (p=0.042 and p=0.045, respectively). FEV1/PEF ratio was the only spirometric parameter that accurately classified those with >50% tracheal narrowing (AUC=0.80). There was no significant association between spirometric values and stenosis complexity. Remarkably, the number of endoscopic procedures during follow-up was inversely correlated with quality of life (r=-0.427, p=0.023).Conclusion: Spirometry is a potential method to predict BTS severity, thus reducing the need of diagnostic bronchoscopies during follow-up.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2844.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).