RT Journal Article SR Electronic T1 The predictive validity for mortality of driving pressure and mechanical power of ventilation JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 3724 DO 10.1183/13993003.congress-2020.3724 VO 56 IS suppl 64 A1 David van Meenen A1 Ary Serpa Neto A1 Frederique Paulus A1 Coen Merkies A1 Laura Schouten A1 Lieuwe Bos A1 Janneke Horn A1 Nicole Juffermans A1 Olaf Cremer A1 Tom Van Der Poll A1 Marcus Schultz YR 2020 UL http://erj.ersjournals.com/content/56/suppl_64/3724.abstract AB Background: Outcome prediction in invasively ventilated ICU patients remains challenging. Driving pressure (ΔP) and mechanical power of ventilation (MP) are associated with outcomes like mortality. The objective of this study was to assess the predictive validity for mortality of ΔP and MP at 24h after start of invasive ventilation.Methods: Posthoc analysis of MARS, a large observational study in two Dutch ICUs. Patients having received invasive ventilation >24h were selected. The primary outcome was 90–day mortality. The predictive validity of ΔP and MP was measured as incremental 90–day mortality beyond that predicted by the Acute Physiology, Age and Chronic Health Evaluation (APACHE) IV score or the Simplified Acute Physiology Score (SAPS) II.Results: A total of 839 patients were included; 90–day mortality was 42%. ΔP (OR for 1 cm H2O increase in ΔP, 1.05 [CI 1.03–1.08] p<0.001) and MP (OR for 0.1 J/min/kg PBW increase in MP, 1.20 [CI 1.09–1.33] P<0.001) were associated with 90–day mortality. However, AUCs of the ROC for 90–day mortality of ΔP and MP added to the APACHE IV score (fig. panel A) and added to the SAPS II (fig. panel B) were not different from that of the APACHE IV score and the SAPS II alone.Conclusions: In this cohort of invasively ventilated ICU patients, ΔP and MP at 24h were associated with 90–day mortality. However, they have no predictive validity beyond that of the APACHE IV score and the SAPS II. FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3724.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).