RT Journal Article SR Electronic T1 Late Breaking Abstract - Telerehabilitation compared to centre-based pulmonary rehabilitation: a randomised controlled equivalence trial JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 4354 DO 10.1183/13993003.congress-2020.4354 VO 56 IS suppl 64 A1 Narelle Cox A1 Christine Mcdonald A1 Ajay Mahal A1 Jennifer Alison A1 Richard Wootton A1 Paolo Zanaboni A1 Catherine Hill A1 Janet Bondarenko A1 Heather Macdonald A1 Kathryn Barker A1 Hayley Crute A1 Christie Mellerick A1 Bruna Wageck A1 Helen Boursinos A1 Aroub Lahham A1 Amanda Nichols A1 Pawel Czuyprn A1 Leah Jennings A1 Monique Corbett A1 Emma Handley A1 Angela Burge A1 Anne Holland YR 2020 UL http://erj.ersjournals.com/content/56/suppl_64/4354.abstract AB Background: Pulmonary rehabilitation is an effective treatment for people with chronic respiratory disease, but is delivered to <5% of eligible individuals. Due to COVID-19 remote rehabilitation models may be critical for future delivery of services.Aims: To compare the efficacy of home-based telerehabilitation (TR) and centre-based pulmonary rehabilitation (PR) in people with chronic respiratory disease.Methods: Assessor blinded, multi-centre RCT, powered for equivalence. Participants were randomised to centre-based PR or home-based TR. Both programs were 2 sessions/week for 8 weeks. Telerehabilitation used a stationary cycle and group videoconferencing to enable social interaction and real time monitoring. The primary outcome was change in chronic respiratory disease questionnaire dyspnea domain (CRQ-D) at end rehabilitation, with a pre-specified equivalence margin of 2.5 points.Results: We randomised 142 participants to PR (n=72) or TR (n=72). Both groups had clinically important improvements in CRQ-D following rehabilitation (TR mean (95%CI) 4 (2 to 5) vs PR 5 (3 to 7)), however equivalence of TR was not confirmed (mean difference between groups (MD) -1 point (-3 to 1)), with similar findings at 12 month followup (MD -1 point (-4 to 1)). The 6-minute walk distance (6MWD) was equivalent at end rehabilitation (MD -6 metres (-26 to 15) and at 12 months superiority of TR could not be excluded (MD 14 metres (-10 to 38). The proportion of participants who completed ≥70% of prescribed sessions was high (84% TR vs 79% PR).Conclusions: Home-based TR achieved clinically important gains in health-related quality of life, but equivalence to centre-based PR was not confirmed.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4354.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).