TY - JOUR T1 - Risk factors in early school age children predict asthma in adulthood JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.410 VL - 56 IS - suppl 64 SP - 410 AU - Laura Healy AU - Angela Simpson AU - Clare S Murray AU - Gina Kerry AU - Lesley Lowe Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/410.abstract N2 - Background: Many studies have investigated risk factors in early life for developing asthma at school age. We investigated risk factors in school-age children in the Manchester and Asthma Study (MAAS) birth cohort for asthma in early adulthood.Aim: To identify which risk factors significantly increase the likelihood of asthma in early adulthood.Methods: Children from MAAS attended follow-up at 8 and 18 years. We defined asthma and non-asthma in participants at age 18. Asthma was defined as all three of the following: wheeze in the previous 12 months, doctor diagnosis of asthma and current use of asthma medication. Non-asthma was defined as none of the above. Univariate and multivariate logistic regression analysis was performed to assess risk factors at age 8 for asthma at age 18.Results: At age 18, 595 completed follow-up; 57 asthma; 347 non-asthma; 191 indeterminate (not included in analysis). Sensitisation to inhaled allergens (OR(95%CI): 6.6(3.6, 12.3)), eczema (5.2(2.7, 9.9)), hay fever (6.0(3.2, 11.2)), FeN0>35ppb (12.4(4.3, 35.6)), positive methacholine challenge (6.7(3.0, 14.9)), and family history of asthma (3.3(1.9, 5.9); all p<0.001) at age 8 were significant risk factors for asthma at age 18. Neither exposure to environmental tobacco smoke (p=0.44) or reduced FEV1/FVC ratio were significant risk factors (p=0.14). In the multivariate analysis, eczema (p=0.004), FeN0>35ppb (p=0.009), positive methacholine challenge (p=0.03) and family history of asthma (p=0.01) remained independent risk factors for asthma at age 18 years.Discussion: Independent risk factors for asthma at age 18 can be identified at age 8 relating to personal and family history of atopy and airway inflammation and reactivity.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 410.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -