TY - JOUR T1 - Secondary pulmonary mycoses etiology agent species diversity in patients with tuberculosis and in patients with HIV infection JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.2074 VL - 56 IS - suppl 64 SP - 2074 AU - Alexandra Gracheva AU - Anna Panova AU - Anatoliy Vinokurov AU - Galina Pay AU - Olga Lovacheva AU - Grigory Kaminskiy AU - Irina Vasilyeva Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/2074.abstract N2 - Secondary pulmonary mycoses etiology agent species diversity in patients with tuberculosis and in patients with HIV infectionIntroduction: In recent years, there has been an increase in the incidence of mycoses. TB and HIV patients are at risk of developing secondary mycoses, the study of the etiology of pathogens is highly demanded.Aims and Objectives: To define of the prevailing classes and species of fungi in TB and HIV patients.Methods: A retrospective analysis of the documentation of in-patients with TB without HIV (N=67) and HIV patients with AIDS (N=121, in 4 patients AIDS was manifested by TB) was carried out. Fungi were diagnosed in etiology specific sites: BAL, biopsy specimens, pleural fluid. Fluorescence microscopy (Calcofluor White with Evans blue), culture studies (Czapek Dox Agar) and PCR-RT were used.Results: In TB patients mold fungi predominate (64.2%), yeast fungi (26.9%) and P.jirovecii (8.9%) were less common. In HIV-infected patients yeast fungi (57.0%) and P.jirovecii were the leaders (29.8%), molds were less common (13.2%). The difference in the distribution is statistically significant (χ2=43.5; p<0.001). In both groups A. fumigatus prevails in molds (46.5% and 17.6%), C. albicans prevails in yeasts (66.7% and 63.8%).Conclusion: In TB patients without HIV mold fungi are most often found, in patients with HIV infection - yeast fungi are the leaders. In both groups A. fumigatus was most common in molds, C. albicans in yeasts.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2074.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -