TY - JOUR T1 - Polymorphisms for epoxide hydrolase, glutathione transferase and genetic susceptibility to COPD JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.3325 VL - 56 IS - suppl 64 SP - 3325 AU - Ariuntungalag Tumurbaatar AU - Ichinnorov Dashtseren AU - Sarantuya Jav AU - Chimedlkhamsuren Ganbold Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/3325.abstract N2 - Background: Chronic Obstructive Pulmonary Disease is a growing public health problem. Tobacco smoke is the risk factor for the COPD. However, only 15% to 20% of smokers develop clinically significant airflow obstruction ⌈Cunhua Yuan, et al.,2017 ⌉, which imply contribution of genetic factors. Genetic susceptibility to the development of COPD might depend on variation in the activities of enzymes the detoxfy cigarette smoke products, such as microsomal epoxide hydrolase (mEPHX) and glutathione S-transferase (GSTs).Objective: To investigate effect of mEPHX, GSTM1, GSTT1 and GSTP1 gene polymorphisms on COPD susceptibility and interaction with smoking dose.Materials and Method: Eighty patients with COPD and eighty healthy subjects who were smokers or ex-smokers enrolled in the case-control study. Genotyping was performed in all participants using polymerase chain reaction and restriction fragment length polymorphism technique.Results: GSTM1-null genotypes were significantly higher in patients with COPD than in control subjects (OR=2.03, 95% CI=1.08-3.82, p=0.027). No significant associations were observed for GSTP1 and GSTT1 gene polymophisms with COPD. On additive interaction analysis a significant positive interactive effect on GSTM1 null and rs1051740 polymorphism with smoking was observed in Mongolian ppulation (RERI=1.787,AP=0.218, S=1.33).Conclusion: Our study demonstrated GSTM1 deletion and rs1051740 polymorphism in EPHX gene significantly interacted with smoking and that both association lead to an increarsed risk for COPD in Mongolian population.Key words: Chronic obstructive pulmonary disease, epoxide hydrolase, glutathione transferase, polymorphismFootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3325.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -