RT Journal Article SR Electronic T1 Effect of different connections on aerosol delivery during non-invasive mechanical ventilation JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1950 DO 10.1183/13993003.congress-2020.1950 VO 56 IS suppl 64 A1 Haitham Saeed A1 Antonio M. Esquinas A1 Bruno Gil Gonçalves A1 Mohamed E.A. Abdelrahim YR 2020 UL http://erj.ersjournals.com/content/56/suppl_64/1950.abstract AB Aims and objectives; the use of nebulizer and pressurized metered-dose inhaler (pMDI) requires a special connection in non-invasive ventilation (NIV) circuit to deliver the drug easily. This study aimed to compare the effect of different connections on aerosol delivery during the NIV.Methods; an in-vitro model consisting of a ventilator, breathing simulator (BS) and connections (Combihaler, Spacer, T-pieces for both nebulizer and pMDI). The connections were placed in the inspiratory arm of the NIV circuit before the Y piece, a filter was placed before BS. Solo nebulizer and pMDI were placed on different connections. 10 runs were done for each connection, in each run 1 ml salbutamol (5000 mcg) was placed in the nebulizer and 2 buffs containing 200 mcg salbutamol were released from the pMDI. Total inhaled dose (TID) and the amount remained in connection were collected and analyzed using HPLC.Results; Combihaler released a higher amount of salbutamol compared to other connections, while the amounts of the drug remaining inside the connection were higher in spacer + t-piece, however, the difference in delivered or amounts deposited in connections was not significant (Table 1).Conclusion; Different connections have comparable efficacy but Combihaler is easier to be used. Hence handmade connections could be used in case of unavailability of the traditional one and also it has a very low cost compared with the traditional one. View this table:Table 1 Mean TID and deposited amounts inside connectionFootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1950.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).