RT Journal Article SR Electronic T1 Electrical impedance tomography in the evaluation of effectiveness of chest physiotherapy JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1269 DO 10.1183/13993003.congress-2020.1269 VO 56 IS suppl 64 A1 Anna Folino A1 Sheila Beux A1 Laura Barrocu A1 Irene Esposito A1 Elvira Rizza A1 Manuela Goia A1 Lorenzo Appendini A1 Elisabetta Bignamini YR 2020 UL http://erj.ersjournals.com/content/56/suppl_64/1269.abstract AB Introduction: Chest physiotherapy, such as PEP mask (with/without an inspiratory pause), plays a role in respiratory management of Cystic Fibrosis (CF) patients. Aims of this study were: 1) to evaluate the PEP mask efficacy in terms of lung inhomogeneity (GI) and end-expiratory lung volume (ΔEELI) reduction as assessed by Electrical impedance tomography (EIT) changes; 2) to evaluate if an inspiratory pause added to PEP mask trials resulted in a greater lung homogeneity/recruitment.Methods: Thirty-two CF patients were enrolled. EIT recording before, during and post PEP mask (5 cycles: 3 cycles with inspiratory pause followed by 2 cycles without pause or vice versa into two randomized subgroups) were taken. A further analysis was performed by considering the pancreatic status.Results: Taken as a whole, data showed that GI was significantly reduced both during each PEP mask cycle (p<0,01) and post-physiotherapy (p<0,05). Subgroups analysis showed that the above results were observed only in those in which the three cycles of PEP mask with inspiratory pause followed the two without it (p<0,01 and p<0,05, during and after physiotherapy, respectively). ΔEELI values did not change throughout the protocol. Patients without pancreatic insufficiency presented significantly reduced GI values both during the PEP mask cycles (p <0,01), and in the post-physiotherapy (p< 0,05); no significant changes in GI emerged in patients with pancreatic insufficiency.Conclusion: In this study we highlighted that EIT can be a valid tool to design chest physiotherapy, evaluate in real time its benefits and to individualize the PEP mask treatment (e.g. in CF patients according to pancreatic status).FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1269.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).