TY - JOUR T1 - Risk Factors for Noninvasive Ventilation Failure in Acute Respiratory Failure with Pneumocystis Jirovecii Pneumonia in Patients without Human Immunodeficiency Virus Infection JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.2020 VL - 56 IS - suppl 64 SP - 2020 AU - Mingming Wang AU - Yunfu Wu AU - Shuoyao Qu AU - Xuemin Yang AU - Liqiang Song Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/2020.abstract N2 - Background: Pneumocystis jirovecii pneumonia (PJP) is one of the main causes for acute respiratory failure (ARF) in immunocompromised hosts with non-HIV infection. Few studies focused on the effect of noninvasive ventilation (NIV) in non-HIV-related PJP (NH-PJP) patients, and the risk factors of NIV failure in these patients are still unclear.Methods: Data of all ARF patients with NH-PJP requiring NIV were retrospectively reviewed in a respiratory intensive care unit from January 2017 to December 2019, and information extracted for identifying the risk factors for NIV failure and mortality.Results: 38 patients were collected and NIV failed in 27 patients(71.1%). The hospital mortality of all PJP patients was 65.8%. PaO2/FiO2 in NIV failure group was significantly lower than that in NIV success group at 1h (103.58±40.73 vs 142.86±60.54, p=0.02) and 24h (94.87±40.19 vs 165.22±83.34, p=0.02) after NIV. The APACHE II score was significantly higher in NIV failure group when using NIV (16.59±3.31 vs 13.55±4.11, p=0.02). The mortality rate in NIV failure group was 88.9% compared with 9% in successful group. Risk factors associated with NIV failure included APACHE II score (Adj. OR: 1.351, 95% CI: 1-1.825, p=0.05) and PaO2/FiO2 at 24h after NIV (Adj. OR: 0.977, 95% CI: 0.961-0.994, p=0.009). NIV failure was significantly associated with hospital survival (Adj. OR: 10, 95% CI: 0.001-0.135, p=0.02).Conclusions: APACHE II score and PaO2/FiO2 at 24h after NIV might predict NIV failure in NH-PJP. The mortality rate of our NH-PJP patients was high, and NIV failure was associated with the higher hospital mortality.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2020.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -