RT Journal Article
SR Electronic
T1 Prediction of lung hyperinflation by forced spirometry: Results from COSYCONET
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2692
DO 10.1183/13993003.congress-2020.2692
VO 56
IS suppl 64
A1 Peter Alter
A1 Jan Orszag
A1 Christina Kellerer
A1 Kathrin Kahnert
A1 Tim Speicher
A1 Henrik Watz
A1 Robert Bals
A1 Tobias Welte
A1 Claus Vogelmeier
A1 Rudolf Jörres
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/2692.abstract
AB Background: Lung hyperinflation is major determinant of prognosis and response to therapy in COPD. It is linked to air trapping and usually determined by body plethysmography or gas dilution. As the availability of these methods is limited, the question arises to which extent hyperinflation can be estimated from spirometry.Methods: We used data from patients of GOLD grades 1–4 obtained in Visits 1–5 of the COPD cohort COSYCONET. Predictive parameters were derived from Visit 1 data, while Visit 2–5 data were used to assess reproducibility. Data from all visits were pooled to determine prediction models for males and females, including age, height and BMI as covariates. Hyperinflation was defined as residual volume to total lung capacity ratio (RV/TLC) above the ULN.Results: Visit 1 data from 1988 patients were available for analysis (FEV1 53.1±18.4 %pred; FVC 78.8±18.8 %pred; RV/TLC 0.547±0.107). In total, 7157 data sets were analyzed. Among measures of hyperinflation, RV/TLC turned out to be most reliable, with FEV1 %pred and FVC %pred being sufficient for prediction. Their relationship to RV/TLC could be depicted in nomograms. Even when neglecting the effects of covariates, RV/TLC above ULN could be predicted by FEV1 %pred, FVC %pred or their combination with an AUC of 0.882, 0.869 and 0.899. Other parameters, i.p. slow inspiratory vital capacity, did not play a role.Conclusions: The degree of hyperinflation in terms of RV/TLC can be estimated from forced spirometry, with an accuracy sufficient for inferring the presence of significant hyperinflation defined by RV/TLC above the upper limit of normal. This may be useful for clinical settings, where body plethysmography is not available.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2692.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).