RT Journal Article
SR Electronic
T1 Sensitivity to Mannitol and Airway Obstruction in Patients with Asthma, COPD and Healthy smokers
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2169
DO 10.1183/13993003.congress-2020.2169
VO 56
IS suppl 64
A1 Abir Nasr
A1 Kerstin Romberg
A1 Linnea Jarenbäck
A1 Leif Bjermer
A1 Ellen Tufvesson
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/2169.abstract
AB Background: Airway hyperresponsiveness (AHR) is often present in patients with asthma and COPD. The aim of this study was to compare the measurements of fractional exhaled nitrogen oxide (FeNO) and forced oscillometry technique (FOT) with spirometry in detecting AHR using mannitol challenge test.Materials & Methods: Totally 285 participants were recruited to this study (Asthma 240, COPD 25, healthy smokers 15 and healthy controls 5). COPD patients had mild/moderate grade of obstruction. FeNO was measured at 50ml/s flow. Subsequently, resistance at 5to19Hz, reactance at 5Hz and spirometry were performed before and after the mannitol challenge test (Aridol®).Results: The positivity to mannitol was 35%in asthmatic patients, 52%in COPD patients, and 47%in healthy smokers. FEV1 correlated significantly with FOT-parameters R5, R19, and X5 both at baseline and at the last dose (p<0.000). Within the groups, healthy smokers and COPD patients had higher R5 at baseline than healthy subjects (p<0.05). R5 at the last dose was significantly increased in healthy smokers (0.004) and COPD patients (P=0.002) compared to healthy subjects. At Baseline X5 was higher among asthma patients compared to COPD patients (p=0.004) and increased further at last dose compared to COPD patients (p=0.003). Among all subjects, FeNO was predominantly increased in asthmatic subjects compared to healthy smokers (p<0.001) and COPD-patients (p<0.05). No correlation was found between FeNO and the positivity to mannitol.Conclusion: Adding the measurement of FOT to the mannitol challenge test increases the sensitivity of the test by characterizing patients with airway obstruction.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2169.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).