TY - JOUR T1 - Effects of High Flow Nasal Cannula on the Coordination between Swallowing and Breathing in Postextubation Patients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.4414 VL - 56 IS - suppl 64 SP - 4414 AU - Pornpan Rattanajiajaroen AU - Napplika Kongpolprom Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/4414.abstract N2 - Background: Timing of swallows in relation to breathing is associated with aspiration. Oxygen therapy possibly affects the swallowing time, which alters airway protective mechanisms.Objectives: To compare the swallowing- breathing coordination between postextubation patients using high flow nasal oxygen(HFNO) and those using low flow nasal oxygen(LFNO).Methods: We conducted a randomized controlled crossover study. The patients extubated within 48 hours were randomly assigned into 2 groups, namely HFNO and LFNO. The study protocol was shown in figure1. The primary outcome was the difference of swallowing-breathing patterns.Results:Twenty-two patients with the mean age of 55.8 years were enrolled. The most common indication for mechanical ventilation was pneumonia with the mean duration of endotracheal intubation of 4.9 days. The mean swallowing frequencies were 6.16 and 7 times per minute in the HFNO and LFNO groups, respectively. The patients using HFNO had higher numbers of E-swallow (74.3% in HFNO vs 67.6% in LFNO; p=0.048) and lower numbers of I-swallow (14.3% in HFNO vs 23.1% in LFNO; p=0.044). The numbers of other swallowing patterns were not different between 2 groups.Conclusion: HFNO significantly increased E-swallow and decreased I- swallow in postextubation patients, compared with LFNO. The findings indicated that HFNO might reduce the risk of aspiration during the postextubation period.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4414.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -