PT - JOURNAL ARTICLE AU - Mohammad Talaei Pashiri AU - Georg Lietz AU - Raquel Granell AU - Seif O. Shaheen TI - Dietary vitamin A intake and lung function in childhood: longitudinal study AID - 10.1183/13993003.congress-2020.4985 DP - 2020 Sep 07 TA - European Respiratory Journal PG - 4985 VI - 56 IP - suppl 64 4099 - http://erj.ersjournals.com/content/56/suppl_64/4985.short 4100 - http://erj.ersjournals.com/content/56/suppl_64/4985.full SO - Eur Respir J2020 Sep 07; 56 AB - Background: Animal data suggest that vitamin A is important for lung growth, but longitudinal epidemiological data are scarce on the relation between dietary intake of vitamin A and lung function.Aims: We investigated whether a higher dietary intake of preformed vitamin A or its major provitamin, β-carotene, in mid-childhood is associated with higher lung function in adolescence.Methods: In the Avon Longitudinal Study of Parents and Children, dietary intake of preformed vitamin A and β-carotene was estimated by food frequency questionnaire at 7 years of age. Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and forced expiratory flow at 25–75% of FVC (FEF25–75) were measured at 15.5 years and were transformed to z-scores based on the Global Lung Function Initiative curves.Results: In 3,680 participants, a higher intake of preformed vitamin A was associated with a higher FEV1 and FEF25–75 (see below). View this table:Table Linear regression coefficients and 95% CI for lung function measures (z scores) according to quartiles of preformed vitamin A intake, adjusted for potential confoundersIn contrast, there was no evidence of association with β-carotene: regression coefficient (95% CI) comparing top vs. bottom quartile was 0.01 (-0.12, 0.14) for FVC, 0.02 (-0.11, 0.15) for FEV1, and -0.01 (-0.13, 0.10) for FEF25–75 (P-trend >0.60).Conclusions: A higher intake of preformed vitamin A, but not β-carotene, in mid-childhood is associated with higher subsequent lung function.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4985.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).