PT  - JOURNAL ARTICLE
AU  - Karampela, Irene
AU  - Chrysanthopoulou, Evangelia
AU  - Simitsis, Panagiotis
AU  - Skyllas, George
AU  - Christodoulatos, Gerasimos Socrates
AU  - Antonakos, George
AU  - Kandri, Evangelia
AU  - Armaganidis, Apostolos
AU  - Dalamaga, Maria
TI  - C-reactive protein/albumin ratio as a prognostic biomarker in critically ill septic patients: a prospective study
AID  - 10.1183/13993003.congress-2020.2751
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 2751
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/2751.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/2751.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Aims and Objectives: Sepsis is an acute life-threatening systemic inflammatory response to infection. C-reactive protein (CRP) and albumin are positive and negative acute phase proteins respectively, following opposing patterns in sepsis. We aim to investigate whether CRP/albumin ratio is a better prognostic marker of 28-day mortality in critically ill patients with sepsis than CRP alone.Methods: In a prospective study, CRP and albumin were determined in serum of 102 critically ill patients (57 males, age 65±15 years, APACHE II 23±7, SOFA 10±3) at sepsis onset and one week after.Results: Thirty patients (29.4%) died within 28 days from enrolment. CRP and CRP/albumin ratio decreased significantly one week after sepsis onset (145±94 vs 91±71mg/L, p<0.001 and 6.5±4.7 vs 4.3±3.8, p<0.001, respectively). Baseline CRP and CRP/albumin ratio were significantly higher in patients presenting with septic shock (N=42) compared to patients with sepsis (N=60) (199±106 vs 106±62mg/L, p<0.001 and 9.4±5 vs 4.5±3, p<0.001) and in nonsurvivors (N=30) compared to survivors (N=72) (196±110 vs 123±78mg/L, p<0.001 and 8.9±5 vs 5.5±4.1, p=0.001) while they did not differ significantly one week after. ROC curve analysis showed that baseline CRP and CRP/albumin ratio performance as predictors of 28-day mortality were similar (AUC: 0.71, 95%CI 0.59-0.82, p=0.001 and 0.70, 95%CI 0.59-0.81, p=0.001, respectively), but outperformed SOFA (AUC 0.66, 95%CI 0.54-0.77, p=0.012) and APACHE II (AUC 0.62, 95%CI 0.51-0.74, p=0.047).Conclusions: CRP/albumin ratio is a good predictor of 28-day mortality in critically ill patients with sepsis, similar to CRP but better than SOFA and APACHE II scores.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2751.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).