PT  - JOURNAL ARTICLE
AU  - Dmytro Dmytriiev
AU  - Kostyantin Dmytriiev
AU  - Kateryna Dmytriieva
TI  - Flow-controlled ventilation (FCV) improves regional ventilation in obese patients with diabetis type 1 and 2
AID  - 10.1183/13993003.congress-2020.339
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 339
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/339.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/339.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Background: In obese patients, high closing capacity and low functional residual capacity increase the risk for expiratory alveolar collapse. We hypothesized that lung aeration and respiratory mechanics improve in obese patients during FCV.Methods: We compared FCV and volume-controlled (VCV) ventilation in 18 obese patients in a randomized crossover setting. Starting with baseline measurements, ventilation settings were kept identical except for the ventilation mode related differences (VCV: inspiration to expiration ratio 1:2 with passive expiration, FCV: inspiration to expiration ratio 1:1 with active, linearized expiration). Primary endpoint of the study was the change of end-expiratory lung volume compared to baseline ventilation. Secondary endpoints were the change of mean lung volume, respiratory mechanics and hemodynamic variables.Results: The loss of end-expiratory lung volume and mean lung volume compared to baseline was lower during FCV compared to VCV (end-expiratory lung volume: FCV, - 144 ± 177 ml; VCV, - 323 ± 232 ml; p < 0.001, mean lung volume: FCV, - 103.4± 188.4 ml; VCV, - 305.8 ± 244.1 ml; p < 0.001) and at comparable plateau pressure (baseline, 18.3 ± 3.8; VCV, 21.4 ± 3.3; FCV, 21.1 ± 3.6 cmH2O; p = 0.432), mean tracheal pressure was higher (baseline, 12.9 ± 1.2; VCV, 12.8 ± 1.23; FCV, 15.1 ± 2.1 cmH2O; p < 0.001). All other respiratory and hemodynamic variables were comparable between the ventilation modes.Conclusions: This study demonstrates that, compared to VCV, FCV improves regional ventilation distribution of the lung at comparable PEEP, tidal volume, Plat and ventilation frequency.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 339.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).