PT  - JOURNAL ARTICLE
AU  - Julien Guiot
AU  - Delphine Zanella
AU  - Pierre-Hugues Stefanuto
AU  - Laurie Giltay
AU  - Monique Henket
AU  - Francoise Guissard
AU  - Catherine Moermans
AU  - Florence Schleich
AU  - Renaud Louis
AU  - Jean-Francois Focant
TI  - Exhaled Volatile Organic Compounds are Able to Diagnose Systemic Sclerosis
AID  - 10.1183/13993003.congress-2020.3545
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 3545
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/3545.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/3545.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Background: The analysis of exhaled breath compounds for systemic sclerosis (SSc) diagnosis offers the possibility of non-invasive diagnosis. The possibility of early diagnostic is a key factor for such aggressive disease with a high overall morbidity. Therefore, easy to use and reproducible biomarker for SSc are highly needed.Methods: We conducted a prospective study on 27 patients with SSc recruited from the university Interstitial and vascular Lung Disease clinic of Liège. Patients underwent volatile organic compound (VOC) measurements and spirometry. Subjects with SSc were classified in two phenotypes: SSc with or without ILD (SSc-ILD).Results: In the SSc group (n=27), 17 patients were suffering from SSc-ILD whereas 4 of them where presenting pulmonary arterial hypertension. There were no significant differences in the treatment between those with or without ILD. We identified 54 specific VOCs in our SSc cohort, compared to HS.Conclusion: Our study identifies for the first time a specific VOC signature for patients with SSc. This preliminary study will undergo further validations.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3545.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).