TY - JOUR T1 - The relationship of thrombus localization with prognosis and chronic tromboembolic pulmonary hypertension in acute pulmonary thromboembolia JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.1861 VL - 56 IS - suppl 64 SP - 1861 AU - Biray Harbiyeli AU - Buğra Özkan AU - Pınar Pelin Özcan AU - Yüksel Balcı AU - Sibel Naycı AU - İsmail Türkay Özcan AU - Eylem Sercan Ozgur AU - Cengiz Özge Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/1861.abstract N2 - Aim: To investigate the relationship between thrombus localization and the development of chronic thromboembolic pulmonary hypertension (CTEPH) in patients with acute pulmonary thromboembolism (PTE) and to determine the risk factors on the development of CTEPH and chronic thromboembolic disease (CTED).Methods: 91 patients who were diagnosed PTE with Computed Thorax Pulmonary Angiography (BTPA) between 2014-2018 and completed at least 3 months of anticoagulant treatment were evaluated. Medical histories, comorbidities, risk factors, symptoms, findings, thrombus localization, medical treatments, venous doppler and echocardiographic examinations, post-treatment symptoms and signs, Troponin-I, NT-proBNP, D-dimer and CRP values were recorded. These data were analyzed for development of CTEPH/CTED and survival.Results: Fifty six (61.5%) of the patients were female. 7 of 91 patients were diagnosed with CTEPH. Right/left ventricular diameter ratio>0.9, 3rd degree tricuspid insufficiency and pulmonary artery pressure (PAP)>36 mmHg has been statistically associated with development of CTEPH within the parameters evaluated at the time of diagnosis(p=0.011,p=0.007,p=0.0001). The thrombus localization in CTPA did not have any effect on survival and development of CTED. Tricuspid insufficiency, NT-proBNP elevation, abnormal findings on chest x-ray after treatment were found statistically significant development of CTED (p=0.009, p<0.0001, p=0.05).Conclusions: Patients with acute PTE should be closely monitored for development of CTEPH and CTED within the follow-up period after initial treatment.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1861.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -