PT  - JOURNAL ARTICLE
AU  - Suzuki, Eiko
AU  - Kawata, Naoko
AU  - Ikari, Jun
AU  - Anazawa, Rie
AU  - Suzuki, Masaki
AU  - Shimada, Ayako
AU  - Tatsumi, Koichiro
TI  - Prognostic nutritional index (PNI): A predictive factor for elderly patients with COPD
AID  - 10.1183/13993003.congress-2020.5114
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 5114
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/5114.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/5114.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Background: Exacerbation causes deterioration of quality of life and worsens respiratory dysfunction, which leads to poor prognosis in patients with COPD. In an aging society, nutritional indices have been reported as significant prognostic factors in many diseases in recent years. However, the relationship between the nutritional indicators and the prognosis in elderly patients with COPD is unknown.Material and Methods: We enrolled Nighty-four subjects who performed spirometry, blood tests, and MDCT. The subjects were divided into two groups according to age: the subjects >75 (n=56) and the subjects < 75(n=38). As a nutritional index, Prognostic Nutritional Index (PNI) were calculated as 10 x serum Albumin + 0.005 x total lymphocyte counts. Then, we examined the relationship between the exacerbation events and clinical parameters including PNI.Results: There was no significant correlation between PNI and FEV1%pred or the percentage of attenuation volume (LAV%). There were significant differences between the groups with/without exacerbation in PNI, serum albumin, and neutrophil-to-lymphocyte ratio(NLR) in patients with age >75. The multivariate analysis showed that FEV1%pred was a significant predictor in the patients age <75, and the nutritional index was most significant predictor in patients with age >75.Conclusion: In patients with age >75, prognostic nutritional index was significantly related to COPD exacerbation risk more than the severity of COPD. Nutritional status may be a potential prediction of clinical course in elderly patients with COPD.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 5114.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).