TY - JOUR T1 - Non-invasive ventilation can modulate the responses of vascular reactivity in COPD-HF patients to high-intensity exercise JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.4416 VL - 56 IS - suppl 64 SP - 4416 AU - Cássia Goulart AU - Flavia Caruso AU - Adriana Araújo AU - Polliana Santos AU - Guilherme Arêas AU - Guilherme Casale AU - Renata Mendes AU - Andréa Da Silva AU - Audrey Borghi-Silva Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/4416.abstract N2 - Aim: to evaluate the acute effects of non-invasive ventilation (NIV) on vascular reactivity to high-intensity exercise in patients with heart failure (HF) and chronic obstructive pulmonary disease (COPD) coexistence.Methods: A randomized double-blinded controlled study involving 12 COPD-HF. Patients performed cardiopulmonary exercise testing (CPET) and two constant workrate tests with NIV (bilevel mode - Astral 150) or Sham until the limit of tolerance. Endothelial function was evaluated by flow mediated vasodilation (FMD) using ultrasound imaging device (I) Pre exercise; (II and III) immediately post exercise (NIV or Sham). Deltas (∆) of the NIV and sham (pre exercise – post-NIV or post-sham) were calculated of variables: absolute FMD, %FMD, blood flow velocity-BFV and shear stress-SS.Results: We found higher ∆FMD (mm) (p=0.01), %FMD (p=0.03), ∆BFV (p=0.04) and ∆SS (p=0.04) with NIV (Figure 1), increase in SpO2peak (%) with NIV compared with Sham 94±3 vs 92±6 (p=0.03). Correlations between SpO2peak of CPET vs FMD(%) post-NIV (p=0.001;r=-0.66); V̇E/V̇CO2 slope of CPET vs FMD(%) post-NIV (p=0.014;r=-0.64).Conclusion: NIV associated to high-intensity exercise improve vasodilation responses and reduce the desaturation. Endothelium vasodilation responses appear to be modulated by the availability of peripheral oxygen.Support: FAPESP:2015/26501-1, 2018/03233-0 and CAPES 001. FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4416.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -