RT Journal Article
SR Electronic
T1 Sleep-disordered breathing and incident malignancy in type 2 diabetes
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2515
DO 10.1183/13993003.congress-2020.2515
VO 56
IS suppl 64
A1 Sarah Driendl
A1 Michael Arzt
A1 Claudia S. Zimmermann
A1 Bettina Jung
A1 Carsten A. Böger
A1 Iris M. Heid
A1 Stefan Stadler
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/2515.abstract
AB Background: Sleep-disordered breathing (SDB) might influence genesis and progression of tumors via intermittent hypoxia and sleep fragmentation. Previous studies show inconsistent results. Examinations on patients with type 2 diabetes (T2D), which is associated with malignancy as well as SDB, are missing.Methods: DIACORE is a prospective study on patients with T2D (observation period 2012 to 2018). Apnoea-hypoponea index (AHI) and the percentage of night`s sleep spent below a peripheral oxygen saturation of 90% (TSat90%) were measured by polygraphy. The malignancy diagnoses were gathered by medical history and validated by medical records. Adjusted hazard ratios (HR) for incident malignancy were calculated by cox regression models accounting for sex, age, body mass index (BMI), smoking status, alcohol intake, and socioeconomic status.Results: Of 1239 patients examined at baseline (mean age 67 years, 41% female, mean BMI 30.9 kg/m²) and followed for a mean of 3.3 ± 1.4 years, 79 (6.4%) developed a malignancy. AHI and TSat90% were not associated with incident malignancy (each p>0.05). In stratified analysis AHI and TSat90% were significantly associated with incident malignancy in women (AHI: HR 1.03, 95% CI [1.00-1.06], p=0.025; TSat90%: HR 1.01, 95% CI [1.00-1.03] , p=0.049), but not in men (p=0.657). Association of AHI and TSat90% with incident malignancy was not significantly different between men and women accounting for known risk factors of malignancy (interaction terms, p=0.092 and p=0.092, respectively).Conclusion: SDB is not associated with incident malignancy in patients with T2D. However, stratified analysis revealed a significant association of SDB with incident malignancy in women, but not in men.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2515.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).