PT - JOURNAL ARTICLE AU - Yao-Wen Kuo AU - Yen-Lin Chen AU - Huey-Don Wu AU - Ying-Chun Chien AU - Chun-Kai Huang AU - Hao-Chien Wang TI - Application of Transthoracic Shear-Wave Ultrasound Elastography in Lung Lesions AID - 10.1183/13993003.02347-2020 DP - 2020 Jan 01 TA - European Respiratory Journal PG - 2002347 4099 - http://erj.ersjournals.com/content/early/2020/10/02/13993003.02347-2020.short 4100 - http://erj.ersjournals.com/content/early/2020/10/02/13993003.02347-2020.full AB - Introduction The tissue stiffness information may help in the diagnosis of lung lesions. This study aimed to investigate and validate the application of transthoracic two-dimensional shear-wave ultrasound elastography in differentiating malignant from benign subpleural lung lesions.Methods This study involved one retrospective observational derivation cohort from January 2016 to December 2017 and one prospective observational validation cohort from December 2017 to December 2019. The inclusion criterion was radiographic evidence of pulmonary lesions. The patients were categorised into the air-bronchogram and hypoechoic groups based on the B-mode grayscale images. The elasticity of subpleural lung lesions with acceptable shear-wave propagation was measured. Diagnoses were made on the basis of pathology, microbiological studies, or following up the clinical course for at least 6 months.Results A total of 354 patients were included. Among the 121 patients in the derivation cohort, a receiver operating characteristic curve was constructed and the cut-off point to differentiate benign from malignant lesions was 65 kPa with Youden index 0.60 and accuracy 84.3%. Among the 233 patients in the validation cohort, the diagnostic performance was maintained with Youden index 0.65 and accuracy 86.7%. Upon applying the cut-off point to the air-bronchogram group, Youden index was 0.70 and accuracy 85.0%.Conclusions This study validated the application of transthoracic shear-wave ultrasound elastography for assessing lung malignancy. A cut-off point of 65 kPa is suggested for predicting lung malignancy. Furthermore, for pulmonary air-bronchogram lesions with high elasticity, tissue proofing should be considered because of the high possibility of malignancy.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Kuo has nothing to disclose.Conflict of interest: Dr. Chen has nothing to disclose.Conflict of interest: Dr. Wu has nothing to disclose.Conflict of interest: Dr. Chien has nothing to disclose.Conflict of interest: Dr. Huang has nothing to disclose.Conflict of interest: Dr. Wang has nothing to disclose.