TY - JOUR T1 - Epidemic and pandemic viral infections: impact on tuberculosis and the lung JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01727-2020 VL - 56 IS - 4 SP - 2001727 AU - Catherine Wei Min Ong AU - Giovanni Battista Migliori AU - Mario Raviglione AU - Gavin MacGregor-Skinner AU - Giovanni Sotgiu AU - Jan-Willem Alffenaar AU - Simon Tiberi AU - Cornelia Adlhoch AU - Tonino Alonzi AU - Sophia Archuleta AU - Sergio Brusin AU - Emmanuelle Cambau AU - Maria Rosaria Capobianchi AU - Concetta Castilletti AU - Rosella Centis AU - Daniela M. Cirillo AU - Lia D'Ambrosio AU - Giovanni Delogu AU - Susanna M.R. Esposito AU - Jose Figueroa AU - Jon S. Friedland AU - Benjamin Choon Heng Ho AU - Giuseppe Ippolito AU - Mateja Jankovic AU - Hannah Yejin Kim AU - Senia Rosales Klintz AU - Csaba Ködmön AU - Eleonora Lalle AU - Yee Sin Leo AU - Chi-Chiu Leung AU - Anne-Grete Märtson AU - Mario Giovanni Melazzini AU - Saeid Najafi Fard AU - Pasi Penttinen AU - Linda Petrone AU - Elisa Petruccioli AU - Emanuele Pontali AU - Laura Saderi AU - Miguel Santin AU - Antonio Spanevello AU - Reinout van Crevel AU - Marieke J. van der Werf AU - Dina Visca AU - Miguel Viveiros AU - Jean-Pierre Zellweger AU - Alimuddin Zumla AU - Delia Goletti Y1 - 2020/10/01 UR - http://erj.ersjournals.com/content/56/4/2001727.abstract N2 - Major epidemics, including some that qualify as pandemics, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A (H1N1)pdm/09 and most recently COVID-19, affect the lung. Tuberculosis (TB) remains the top infectious disease killer, but apart from syndemic TB/HIV little is known regarding the interaction of viral epidemics and pandemics with TB. The aim of this consensus-based document is to describe the effects of viral infections resulting in epidemics and pandemics that affect the lung (MERS, SARS, HIV, influenza A (H1N1)pdm/09 and COVID-19) and their interactions with TB. A search of the scientific literature was performed. A writing committee of international experts including the European Centre for Disease Prevention and Control Public Health Emergency (ECDC PHE) team, the World Association for Infectious Diseases and Immunological Disorders (WAidid), the Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycobacterial Infections (ESGMYC) was established. Consensus was achieved after multiple rounds of revisions between the writing committee and a larger expert group. A Delphi process involving the core group of authors (excluding the ECDC PHE team) identified the areas requiring review/consensus, followed by a second round to refine the definitive consensus elements. The epidemiology and immunology of these viral infections and their interactions with TB are discussed with implications for diagnosis, treatment and prevention of airborne infections (infection control, viral containment and workplace safety). This consensus document represents a rapid and comprehensive summary on what is known on the topic.This consensus statement describes the effects of the viral infections resulting in epidemics and pandemics affecting the lung (MERS, SARS, HIV, influenza A (H1N1)pdm/09 and COVID-19) and their interactions with TB, the top infectious disease killer https://bit.ly/2UUjhGu ER -