TY - JOUR T1 - Effect of history of tuberculosis on specificity of Xpert MTB/RIF JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00343-2020 VL - 56 IS - 3 SP - 2000343 AU - Frederick Haraka AU - Samuel G. Schumacher AU - Amanda Ross AU - Anna Mantsoki AU - Sebastien Gagneux AU - Klaus Reither AU - Claudia M. Denkinger Y1 - 2020/09/01 UR - http://erj.ersjournals.com/content/56/3/2000343.abstract N2 - Tuberculosis (TB) is the leading cause of mortality among infectious diseases. In 2018, 1.5 million people died due to TB [1]. Early diagnosis of TB is key in achieving WHO End TB targets, and molecular diagnostic tests have been developed. However, molecular tests cannot differentiate between viable and non-viable bacteria [2, 3], leading to challenges in the interpretation of positive test results in patients with recent TB.Specificity of Xpert MTB/RIF was lower in those with tuberculosis (TB) history compared to those without TB history and specificity increased as time since previous TB increased https://bit.ly/2W4hWfXWe acknowledge all study teams, FIND data team and Ramadhani Abdul, a statistician at Ifakara Health Institute, for their support during data extraction and management. ER -