TY - JOUR T1 - Ozone exposure leads to changes in airway permeability, microbiota and metabolome: a randomised, double-blind, crossover trial JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00165-2020 VL - 56 IS - 3 SP - 2000165 AU - Yue Niu AU - Renjie Chen AU - Cuiping Wang AU - Weidong Wang AU - Jing Jiang AU - Weidong Wu AU - Jing Cai AU - Zhuohui Zhao AU - Xiaohui Xu AU - Haidong Kan Y1 - 2020/09/01 UR - http://erj.ersjournals.com/content/56/3/2000165.abstract N2 - The associations between atmospheric ozone pollution and increased risks of respiratory diseases have been well established [1, 2], but the underlying biological mechanisms are not fully ascertained. Lung epithelial cells may be injured by inhaled ozone, but results have not been fully consistent [3, 4]. Furthermore, respiratory microbiota and metabolic homeostasis have been deemed to be key factors in maintaining human respiratory health, and any disturbances in this balance have the potential to increase susceptibility to respiratory infectious diseases [5]. However, few human studies have investigated the potential effects of ozone inhalation on respiratory microbiota and metabolome.Ozone inhalation could lead to depleted diversity of respiratory bacterial community, imbalanced proportion between commensal and pathogenic bacteria, and elevated levels of glucose and its metabolites in respiratory tract https://bit.ly/2JS9OJQ ER -