TY - JOUR T1 - Confocal LASER endomicroscopy in Niemann–Pick disease type B JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02306-2020 SP - 2002306 AU - Thomas Villeneuve AU - Nicolas Guibert AU - Samia Collot AU - Pierre Fajadet AU - Magali Colombat AU - Monique Courtade-Saïdi AU - Thierry Levade AU - Alain Didier AU - Grégoire Prévot Y1 - 2020/01/01 UR - http://erj.ersjournals.com/content/early/2020/08/28/13993003.02306-2020.abstract N2 - A 41-year-old female was referred to our institution for the recent worsening of a chronic cough and dyspnea that had slowly increased over the past 6 years. She had never smoked, had no notable medical history and was not under any medication. She had two healthy children and no past family history. In 1999, some first pulmonary function tests (PFT) were performed in another center to explore her chronic cough, showing a subnormal forced vital capacity (FCV, 2.64 L, 95% of predicted) and diffusing capacity for carbon monoxide (DLCO, 90% of predicted). The chest computed tomography (CT) showed an interstitial lung disease (ILD) with interlobular septa thickening in the upper lobes associated with ground glass opacities (fig. 1a). No definitive diagnosis was made and the patient was lost to follow-up. 20 years later, she was referred to our pulmonology department for further investigation of a recent worsening of her cough and a slowly progressive dyspnea. The clinical examination was unremarkable, except for the perception of crackles in the bases. Her saturation was of 97% on room air.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Villeneuve has nothing to disclose.Conflict of interest: Dr. Guibert has nothing to disclose.Conflict of interest: Dr. Collot has nothing to disclose.Conflict of interest: Dr. Fajadet has nothing to disclose.Conflict of interest: Dr. Colombat has nothing to disclose.Conflict of interest: Dr. Courtade-Saïdi has nothing to disclose.Conflict of interest: Dr. Levade has nothing to disclose.Conflict of interest: Dr. Didier reports personal fees from Astra Zeneca, personal fees from GSK, personal fees from ALK, personal fees from Novartis, personal fees from Boehringer Ingelheim, outside the submitted work.Conflict of interest: Dr. Prévot has nothing to disclose. ER -