TY - JOUR T1 - Diagnosing adrenal insufficiency using ACTH stimulation test JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01478-2020 VL - 56 IS - 2 SP - 2001478 AU - Brian Lipworth AU - Rory Chan AU - Chris RuiWen Kuo Y1 - 2020/08/01 UR - http://erj.ersjournals.com/content/56/2/2001478.abstract N2 - We read with interest the real-world data of Nanzer et al. [1], looking at adrenal insufficiency (AI) in severe asthma patients taking oral corticosteroid-sparing anti-interleukin (IL)-5 therapy. They reported that 43% of patients apparently failed a short adrenocorticotropic hormone (ACTH) stimulation test associated with a median baseline morning serum cortisol of 86 nmol·L−1 and a median prednisolone dose of 5 mg. We would be interested to know the mean cortisol level after ACTH, as well as the percentage of patients who failed to achieve a post-ACTH level of 500 nmol·L−1 which is the accepted cut-off for impaired response [2, 3].Low dose ACTH stimulation test is more likely to detect adrenal insuffiency in patients being weaned off oral corticosteroids https://bit.ly/2XsMA3i ER -