TY - JOUR T1 - Thrombosis and COVID-19 pneumonia: the clot thickens! JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01608-2020 VL - 56 IS - 1 SP - 2001608 AU - Laura C. Price AU - Colm McCabe AU - Ben Garfield AU - Stephen J. Wort Y1 - 2020/07/01 UR - http://erj.ersjournals.com/content/56/1/2001608.abstract N2 - At the end of last year, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulted in an acute respiratory illness epidemic in Wuhan, China [1, 2]. The World Health Organization (WHO) termed this illness coronavirus disease 2019 (COVID-19). The coronavirus family have been shown to enter cells through binding angiotensin-converting enzyme 2 (ACE-2), found mainly on alveolar epithelium and endothelium. Activation of endothelial cells is thought to be the primary driver for the increasingly recognised complication of thrombosis.Pulmonary thrombosis appears to be common in COVID-19 pneumonia and takes two forms, proximal pulmonary emboli and/or distal thrombosis. The possible mechanisms and clinical implications are discussed. https://bit.ly/372XdhwThe authors would like to acknowledge Deepa Arachchillage, consultant haematologist, Royal Brompton Hospital. ER -