RT Journal Article
SR Electronic
T1 Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2001875
DO 10.1183/13993003.01875-2020
A1 Antoine Beurnier
A1 Etienne-Marie Jutant
A1 Mitja Jevnikar
A1 Athénaïs Boucly
A1 Jérémie Pichon
A1 Mariana Preda
A1 Marie Frank
A1 Jérémy Laurent
A1 Christian Richard
A1 Xavier Monnet
A1 Jacques Duranteau
A1 Anatole Harrois
A1 Marie-Camille Chaumais
A1 Marie-France Bellin
A1 Nicolas Noël
A1 Sophie Bulifon
A1 Xavier Jaïs
A1 Florence Parent
A1 Andrei Seferian
A1 Laurent Savale
A1 Olivier Sitbon
A1 David Montani
A1 Marc Humbert
YR 2020
UL http://erj.ersjournals.com/content/early/2020/07/23/13993003.01875-2020.abstract
AB Background Viral respiratory infections are the main causes of asthma exacerbation. The susceptibility of asthmatics to develop an exacerbation when they present with severe pneumonia due to SARS-CoV-2 infection is unknown. The objective of this study was to investigate the characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who required hospitalisation during the spring 2020 outbreak in Paris, France.Methods A prospective cohort follow-up was carried out from March 15 to April 15, 2020 in Bicêtre Hospital, University Paris-Saclay, France. All hospitalised patients with a SARS-CoV-2 infection who reported a history of asthma were included.Results Among 768 hospitalised patients, 37 (4.8%) reported a history of asthma, which had been previously confirmed by a pulmonologist in 85% of cases. Patients were mainly female (70%), non-smokers (85%), with a median age of 54 years (interquartile range, IQR 42–67). None of them presented with an asthma exacerbation. Twenty-two (59%) had major comorbidities and 31 (84%) had a body mass index ≥25 kg·m−2. The most common comorbidities were obesity (36%), hypertension (27%) and diabetes (19%). All patients had a confirmed diagnosis of COVID-19 pneumonia on computed tomography of the chest. Eosinopenia was a typical biologic feature with a median count of 0/mm3 (IQR 0–0). Eleven patients (30%) were admitted in intensive care unit with three death (8.1%) occurring in the context of comorbidities.Conclusion Asthmatics were not overrepresented among patients with severe pneumonia due to SARS-CoV-2 infection who required hospitalisation. Worst outcomes were observed mainly in patients with major comorbidities.Asthmatics were not overrepresented among patients with severe pneumonia due to SARS-CoV-2 infection who require hospitalisation. None of them presented with an asthma exacerbation. Worst outcomes were observed mainly in patients with major comorbidities.