TY - JOUR T1 - Response to “COVID-19 conundrum: Clinical phenotyping based on pathophysiology as a promising approach to guide therapy in a novel illness” and “Strengthening the foundation of the house of CARDS by phenotyping on the fly” and “COVID-19 phenotypes: leading or misleading?” JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02756-2020 SP - 2002756 AU - Lieuwe D.J. Bos AU - Pratik Sinha AU - Robert P. Dickson Y1 - 2020/01/01 UR - http://erj.ersjournals.com/content/early/2020/07/16/13993003.02756-2020.abstract N2 - In their letter, Drs. Cherian et al. take issue with our interpretation of the respiratory physiology of COVID-19, arguing that it is based merely on “small cohort studies,” instead arguing that “a high proportion of mechanically ventilated COVID-19 patients exhibit near-normal lung compliance” [1]. Yet the low respiratory compliance of COVID-19 patients has now been extensively demonstrated by studies totalling more than 800 COVID-19 patients [2–8], including a direct comparison with non-COVID ARDS patients that revealed no difference in respiratory compliance [8].We argue that phenotyping of COVID-19 related ARDS should be done using careful, data-driven approaches. ER -