TY - JOUR T1 - A randomised trial of high-flow nasal cannula in infants with moderate bronchiolitis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01926-2019 VL - 56 IS - 1 SP - 1901926 AU - Philippe Durand AU - Tamazoust Guiddir AU - Christèle Kyheng AU - Florence Blanc AU - Olivier Vignaud AU - Ralph Epaud AU - Frédéric Dugelay AU - Isabelle Breant AU - Isabelle Badier AU - Vanessa Degas-Bussière AU - Florence Phan AU - Valérie Soussan-Banini AU - Agnès Lehnert AU - Célestin Mbamba AU - Catherine Barrey AU - Cédric Tahiri AU - Marion Decobert AU - Marie Saunier-Pernaudet AU - Irina Craiu AU - Mélanie Taveira AU - Vincent Gajdos Y1 - 2020/07/01 UR - http://erj.ersjournals.com/content/56/1/1901926.abstract N2 - Background The objective was to determine whether high-flow nasal cannula (HFNC), a promising respiratory support in infant bronchiolitis, could reduce the proportion of treatment failure requiring escalation of care.Methods In this randomised controlled trial, we assigned infants aged <6 months who had moderate bronchiolitis to receive either HFNC at 3 L·kg−1·min−1 or standard oxygen therapy. Crossover was not allowed. The primary outcome was the proportion of patients in treatment failure requiring escalation of care (mostly noninvasive ventilation) within 7 days following randomisation. Secondary outcomes included rates of transfer to the paediatric intensive care unit (PICU), oxygen, number of artificial nutritional support-free days and adverse events.Results The analyses included 268 patients among the 2621 infants assessed for inclusion during two consecutive seasons in 17 French paediatric emergency departments. The percentage of infants in treatment failure was 14% (19 out of 133) in the study group, compared to 20% (27 out of 135) in the control group (OR 0.66, 95% CI 0.35–1.26; p=0.21). HFNC did not reduce the risk of admission to PICU (21 (15%) out of 133 in the study group versus 26 (19%) out of 135 in the control group) (OR 0.78, 95% CI 0.41–1.41; p=0.45). The main reason for treatment failure was the worsening of modified Wood clinical asthma score (m-WCAS). Short-term assessment of respiratory status showed a significant difference for m-WCAS and respiratory rate in favour of HFNC. Three pneumothoraces were reported in the study group.Conclusions In patients with moderate bronchiolitis, there was no evidence of lower rate of escalating respiratory support among those receiving HFNC therapy.This randomised trial found no evidence of lower rate of escalating respiratory support among patients receiving high-flow oxygen therapy admitted for a first episode of moderate bronchiolitis to the paediatric emergency department https://bit.ly/2xsvqJG ER -